Medical Aesthetic Procedures

Polynucleotides: A Look at Their Effectiveness in the Under Eye Area

Polynucleotides are naturally occurring substances found in DNA and RNA, the genetic material that serves as the blueprint for our cells. PDRN is known for its ability to stimulate tissue repair, enhance collagen production, and improve overall skin texture. These properties make it a compelling ingredient for addressing common under-eye concerns like dark circles, puffiness, and fine lines.

The Under Eye Area

The skin around the eyes is exceptionally thin and delicate, making it prone to various signs of aging and fatigue. It’s a really tricky area to treat!

Factors like genetics, sun exposure, lack of sleep, and lifestyle choices can contribute to the appearance of dark circles, puffiness, and fine lines in this area. To effectively target these issues, skincare ingredients need to be carefully chosen, as the under eye area requires specialised care.

Polynucleotides and the Under Eye Area

  • Improved Circulation: Dark circles are often the result of poor blood circulation beneath the eyes. Polynucleotides have been shown to enhance microcirculation, which can help reduce the appearance of dark circles by promoting better blood flow and oxygenation of the skin.
  • Collagen Production: Collagen is a vital protein that provides structural support to the skin. As we age, collagen production decreases, leading to the formation of fine lines and wrinkles. Polynucleotides can stimulate collagen synthesis, leading to smoother and firmer skin in the under-eye area.
  • Hydration and Elasticity: Hydration is essential for maintaining the elasticity and suppleness of the skin. Polynucleotides help improve the skin's moisture retention capacity, resulting in plumper and more youthful-looking under-eye skin.
  • Anti-Inflammatory Properties: Puffiness and swelling around the eyes can be caused by inflammation. Polynucleotides have anti-inflammatory properties that can help reduce under-eye puffiness and promote a refreshed appearance.

Where’s the evidence?!

Several studies have examined the effectiveness of polynucleotides in skincare, including their application in the under-eye area. These studies have reported significant improvements in skin hydration, elasticity, and overall appearance, making polynucleotides a promising ingredient for under-eye treatments.

How to Incorporate Polynucleotides into Your Skincare Routine

When considering using polynucleotides in your skincare routine, it's essential to consult with a dermatologist or skincare professional. They can provide personalised advice and recommend products specifically formulated for the under-eye area.


The use of polynucleotides in skincare, especially in the under-eye area, holds promise for those seeking effective solutions for concerns like dark circles, puffiness, and fine lines. With its ability to stimulate collagen production, improve circulation, and hydrate the skin, polynucleotides offer a multi-faceted approach to rejuvenating the delicate skin around the eyes.

It’s always important to remember that ondividual results may vary. I think it’s always important to look at skin care as an ongoing journey but polynucleotides are definite a good tool to work with!

As the science of skincare continues to evolve, polynucleotides are undoubtedly an exciting addition to the arsenal of ingredients designed to help us achieve a fresh glow!


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