Hyaluronidase is an enzyme used to break down hyaluronic acid which is the main constituent of many dermal fillers. It was originally discovered in 1929 by Dr Francisco Duran-Reynals, a Spanish doctor in pathology.
Before the popularity of hyaluronic acid based dermal fillers, hyaluronidased as used to increase uptake of local anaesthetic (numbing agents) and used in conjunction with other injected medications to increase its spread.
Initially noticed to be found in strains of streptococcal bacteria, it is now sourced from sheep. It's use in the aesthetics industry is in fact, 'off label' but it is widely accepted to be the most effective way of managing vascular occlusions, lumps and nodules and misplaced dermal filler.
When injected into the treatment area, the hyaluronidase will dissolve both synthetic and naturally occuring hyaluronic acid so its best avoided if possible. Treatment with dermal filler should be delayed for at least 3 weeks after dissolving.